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人员:

教师队伍:孙伟、徐弢、弥胜利

工程师及实验室秘书: 徐圆圆、张丽蓉

博士后:马原、刘旭杰

博士生:孔彬、郭钟伟、刘伯勋

硕士生:杜志昌、吴啸跃、郭潇、易晓满、胡颖英、杨帅涛、夏静静、蒲海涛、李柏翰、夏圣跃、刘兆宇、施燕捷、周一鸣

出站博士后:刘长勇、吴正洁

毕业硕士生:刘多静、苏鑫、徐圆圆


简介:生物制造是一门以细胞、活性分子和生物材料为基本单元的仿生结构体的制造科学,是工程、材料、信息和生命科学交叉的新兴学科。生物制造的科学、技术和应用广涵于仿生制造、功能结构生物体制造、再生医学模型制造、体外生物/病理/药理模型制造及以细胞和活性分子为基础的细胞/组织/器官芯片和先进医疗诊断设备的制造。探索并开拓现代工程和制造科学在生物、生物工程及生物医学中的应用新领域,并促进生物制造新兴学科的发展。

中心目标:建立世界一流、在生物制造领域具有国际影响力的科研、教育、人才培养和技术应用交叉前沿学科研究中心、探索并开拓现代工程和制造科学在生物工程和生物医学中的应用新领域。促进和引领生物制造新兴学科的发展

代表性成果:

自主研发的生物支架三维打印设备:低温沉积制造工艺是一种新型将材料的挤压/喷射过程和热致相分离过程集成起来的组织工程支架快速成形工艺,已应用于骨组织工程的研究中。

   

[1] Mi SDu ZXu YWu ZQian XZhang MSun W. Microfluidic co-culture system for cancer  migratory analysis and  anti

    metastatic drugs screening. Sci Rep. 2016 , 20;6:35544. doi: 10.1038/srep35544. (IF=5.578).

[2] Xujie Liu, Tarek A Elkhooly, Qianli Huang, Wei He, Qiang Cai, Qingling Feng*, and Shengli Mi*. A Facile Way to Prepare Mesoporous Spherical Calcites Controlled by Chondroitin Sulfate for Shape and Carboxymethyl Chitosan for Siz. CrystEngComm, 2016, 00, 1-5.(corresponding author, IF=3.849)

[3] Xujie Liu, Tarek A. Elkhooly, Ranran Zhang, Qingling Feng*, Akash Bachhukad, Krasimir Vasilevd, Qiang Cai, Shengli Mi*. Selective deposition of CaCO3 on chemical gradient surface generated by plasma polymerization and its effect on cell adhesion. Materials Letters 186 (2017) 90–93. corresponding author, IF=2.437)

[4] Liu XYu BHuang QLiu RFeng QCaiabd QMi S*. In vitro BMP -2 peptide release from thiolated chitosan based hydrogel. Int J Biol Macromol. 2016 ,93 (16)314-321(corresponding author, IF=3.138)

[5] Bin Kong and Shengli Mi*. Electrospun Scaffolds for Corneal Tissue Engineering: A Review. Materials 2016, 9, 614; doi:10.3390/ma9080614(corresponding author, IF=2.728)

[6] Wu Z, Su X, Xu Y, Kong B, Sun W, Mi S*. Bioprinting three-dimensional cell-laden tissue constructs with controllable degradation. Scientific Report. 2016 19; 6:24474. doi: 10.1038/srep24474.( corresponding author, IF=5.578)

[7] Liu XNZhu XPWu JWu ZJYin YXiao XHSu XKong BPan SYYang HCheng YAn N1, Mi SL*. Acellular ostrich corneal stroma used as scaffold for construction of tissue-engineered cornea. Int J Ophthalmol. 2016 Mar 18;9 (3):325-31. (corresponding author, IF=0.705)

[8] Mi S*, Kong B, Wu Z, Sun W, Xu Y, Su X. A novel electrospinning setup for the fabrication of thickness-controllable3Dscaffoldswithanorderednanofibrous structure. Materials Letters 160:343-346,2015. (corresponding author, IF=2.489)

[9] Xiao X,Pan S,Liu X,Zhu X,Connon CJ,Wu J,Mi S*. In vivo study of the biocompatibility of a novel compressed collagen hydrogel scaffold for artificial corneas. Journal of Biomedical Materials Research: Part A 102 (6):1782-1787,2014. (corresponding author, IF=2.625)

[10] Liu CLi YZhang LMi SXu YSun W. Development of a novel low temperature deposition machine using screw extrusion to fabricate PLGA scaffolds. Proceedings of IMechE, Part H: Journal of Engineering in Medicine. 2014, 228(6):593-606. (IF=1.419)

[11] Liu XN, An N, Wu J, Xu K, Zhu XP, Mi S.* Corneal ulcer caused by nocardia brasiliensis in a patient with diabetes. Int J Ophthalmology 7(2):381-383,2014. (corresponding author, IF=0.12)

[12] Wright BMi SConnon CJ. Towards the use of hydrogels in the treatment of limbal stem cell deficiency. Drug Discov Today,18(1-2):79-86,2013.(co-first author,IF=6.828) 

@2018 清华大学深圳研究生院先进制造学部 地址:深圳大学城清华园区 邮编:518055 Email:xjzzxb@sz.tsinghua.edu.cn